CNGB3 Antibody

Immunohistochemistry-Paraffin: CNGB3 Antibody [NBP2-75087] - Negative Control showing staining of paraffin embedded Human Retina, with no primary antibody.

Immunohistochemistry-Paraffin: CNGB3 Antibody [NBP2-75087] - (2ug/ml) staining of paraffin embedded Human Retina. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.

• Reactivity: Hu, Pm
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

CNGB3 Antibody Summary

• Description: Novus Biologicals Goat CNGB3 Antibody (NBP2-75087) is a polyclonal antibody validated for use in IHC and ELISA. Anti-CNGB3 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-ESDDKPTEHYYR, from the internal region of the protein sequence according to NP_061971.3.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CNGB3
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 2-4 ug/ml
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 2-4 ug/ml
  • Peptide ELISA 1:8000
• Application Notes: Use in Immunohistochemistry-Frozen reported in scientific literature (PMID:35024589)..

Reactivity Notes

Use in Monkey reported in scientific literature (PMID:35024589) .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: TBS (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Antigen Affinity-purified

Alternate Names for CNGB3 Antibody

• cyclic nucleotide gated channel beta 3

Background

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 . Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CNGB3 Antibody (NBP2-75087)(1)

Publication using NBP2-75087

• Yamasaki S, Tu H, Matsuyama T et al. A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation iScience 2022-01-01 [PMID: 35024589] (IHC-Fr, Monkey)

Bioinformatics

• Gene Symbol: CNGB3