CLN6 Antibody

Product Discontinued

CLN6 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 229-274 of Human CLN6.
• Specificity: CLN6 (N258) detects endogenous levels of CLN6 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CLN6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of CLN6 (N258) pAb in extracts from HeLa cells.
  Immunohistochemistry (IHC) analyzes of CLN6 (N258) pAb in paraffin-embedded human cervix carcinoma tissue.
• Theoretical MW: 40 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

This antibody is reactive against Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CLN6 Antibody

• ceroid-lipofuscinosis neuronal protein 6
• ceroid-lipofuscinosis, neuronal 6, late infantile, variant
• FLJ20561
• HsT18960
• nclf
• Protein CLN6

Background

CLN6, a 311-amino acid protein, has 7 predicted transmembrane domains and is conserved across vertebrates. The CLN6 protein localizes to the endoplasmic reticulum but contributes to lysosomal function. Mutations in the CLN6 gene cause variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL), a lysosomal storage disorder marked by progressive mental deterioration and blindness; part of a group of severe inherited neurodegenerative disorders affecting children wherein lysosomes accumulate storage material, causing the death of neurons. CLN6 is one of eight proteins, including CLN1-8, that are associated with NCL.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLN6
• Entrez:
  • 54982(Human)