CIZ1 Antibody

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Independent Antibodies: Western Blot: CIZ1 Antibody [NB100-74624] - Detection of Human CIZ1on HeLa whole cell lysate using NB100-74624. CIZ1 was also immunoprecipitated by rabbit anti-CIZ1 antibody NB100-74623.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
Validated by:
 

Independent Antibodies

       

Order Details

CIZ1 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 848 and 898 of human CDKN1A interacting zinc finger protein 1 using the numbering given in entry NP_036259.2 (GeneID 25792).
Localization
Cytoplasmic and Nuclear
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CIZ1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunocytochemistry/Immunofluorescence
  • Immunoprecipitation 2-5 ug/mg lysate
Application Notes
Use in ICC/IF reported in scientific literature (PMID 28546514).
Publications
Read Publications using
NB100-74624 in the following applications:

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28546514).

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CIZ1 Antibody

  • CDKN1A interacting zinc finger protein 1
  • CDKN1A-interacting zinc finger protein 1
  • cip1-interacting zinc finger protein
  • LSFR1ZNF356Nuclear protein NP94
  • NP94
  • Zinc finger protein 356

Background

CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CIZ1 Antibody (NB100-74624)(3)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ICC/IF, WB.


Filter By Application
ICC/IF
(1)
WB
(1)
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Mouse
(1)
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Showing Publications 1 - 3 of 3.
Publications using NB100-74624 Applications Species
Ridings-Figueroa R, Stewart ER, Nesterova TB et al. The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory. Genes Dev. May 25 2017 [PMID: 28546514] (ICC/IF, Mouse) ICC/IF Mouse
Coverley D, Higgins G, West D et al. A quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma. Clin. Biochem. Nov 17 2016 [PMID: 27867087] (WB) WB
Markaki Y, Chong J, Luong C et al. Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome bioRxiv Nov 23 2020

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol CIZ1
Entrez
Uniprot