CIZ1 Products

Description

CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

Bioinformatics

Entrez	25792 Human
Uniprot	AAH21163 Human AAH21163.1 Human NP_001124488 Human NP_036259 Human NP_036259.2 Human Q9ULV3 Human
Product By Gene ID	25792
Alternate Names	CDKN1A interacting zinc finger protein 1 CDKN1A-interacting zinc finger protein 1 cip1-interacting zinc finger protein LSFR1ZNF356Nuclear protein NP94 NP94 Zinc finger protein 356

Research Areas for CIZ1

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Cancer