cIAP-2/HIAP-1 Antibody

Product Discontinued

cIAP-2/HIAP-1 Antibody Summary

• Immunogen: Peptide with sequence C-SVNNLEATSQP corresponding to internal region according to NP_001156.1.
• Epitope: C-SVNNLEATSQP
• Specificity: Reported variants represent identical protein: NP_892007.1, NP_001156.1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: BIRC3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Experiments gave bands at approx. 70 kDa band and 52 kDa band in rat testis lysates. These bands correspond to earlier findings with different antibodies from other sources. This protein has a calculated MW of 67.3 kDa band according to rat NP_076477.2.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for cIAP-2/HIAP-1 Antibody

• AIP1
• API2
• BIRC3 baculoviral IAP repeat containing 3
• BIRC3
• cIAP2
• c-IAP2
• cIAP-2
• HAIP1
• HIAP1
• HIAP-1
• MALT2
• MIHC
• RNF49

Background

cIAP2 is an apoptotic suppressor. Apoptosis is activated by an array of stimuli including members of the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. These proteins contain a baculovirus IAP repeat (BIR) domain which interact with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). This complex may play a role in the inhibition of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for cIAP-2/HIAP-1 Antibody (NBP1-52091)(1)

Publication using NBP1-52091

• Zheng C, Kabaleeswaran V, Wang Y et al. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell 2010-04-01 [PMID: 20385093]

Bioinformatics

• Gene Symbol: BIRC3
• Entrez:
  • 330(Human)
• Uniprot:
  • NP_001156.1(Human)