cIAP-2/HIAP-1 Antibody

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Western Blot: cIAP-2/HIAP-1 Antibody [NBP1-52091] - Analysis of cIAP2 in Rat Testis lysate (35ug protein in RIPA buffer) using NBP1-52091 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

cIAP-2/HIAP-1 Antibody Summary

Immunogen
Peptide with sequence C-SVNNLEATSQP corresponding to internal region according to NP_001156.1.
Epitope
C-SVNNLEATSQP
Specificity
Reported variants represent identical protein: NP_892007.1, NP_001156.1.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
BIRC3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Experiments gave bands at approx. 70 kDa band and 52 kDa band in rat testis lysates. These bands correspond to earlier findings with different antibodies from other sources. This protein has a calculated MW of 67.3 kDa band according to rat NP_076477.2.
Publications
Read Publication using NBP1-52091.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for cIAP-2/HIAP-1 Antibody

  • AIP1
  • API2
  • BIRC3 baculoviral IAP repeat containing 3
  • BIRC3
  • cIAP2
  • c-IAP2
  • cIAP-2
  • HAIP1
  • HIAP1
  • HIAP-1
  • MALT2
  • MIHC
  • RNF49

Background

cIAP2 is an apoptotic suppressor. Apoptosis is activated by an array of stimuli including members of the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. These proteins contain a baculovirus IAP repeat (BIR) domain which interact with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). This complex may play a role in the inhibition of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for cIAP-2/HIAP-1 Antibody (NBP1-52091)(1)

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Diseases for cIAP-2/HIAP-1 Antibody (NBP1-52091)

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Blogs on cIAP-2/HIAP-1.

cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and...  Read full blog post.

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Bioinformatics

Gene Symbol BIRC3
Entrez
Uniprot