Chitotriosidase/CHIT1 Antibody (397504) [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: IP, B/N
• Clone: 397504
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 610 SE

Chitotriosidase/CHIT1 Antibody (397504) [mFluor Violet 610 SE] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Chitotriosidase/CHIT1
  Ala22-Asn466
  Accession # Q13231
• Specificity: Detects human Chitotriosidase/CHIT1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human CHI3L1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CHIT1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Neutralization
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Chitotriosidase/CHIT1 Antibody (397504) [mFluor Violet 610 SE]

• CHI3
• CHIT1
• CHITCHI3
• chitinase 1 (chitotriosidase)
• chitinase-1
• Chitotriosidase
• chitotriosidase-1
• EC 3.2.1.14
• FLJ00314
• MGC125322
• plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase

Background

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CHIT1