Cdk5 Antibody (DC17+DC34)

Product Discontinued

Cdk5 Antibody (DC17+DC34) Summary

• Immunogen: BALB/C mice were injected with a recombinant cdk5 protein.
• Clonality: Monoclonal
• Host: Mouse
• Gene: CDK5
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:100

Reactivity Notes

Mouse,Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS with BSA
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Cdk5 Antibody (DC17+DC34)

• CDK5
• CDKN5
• Cell division protein kinase 5
• cyclin-dependent kinase 5
• EC 2.7.11
• EC 2.7.11.22
• LIS7
• protein kinase CDK5 splicing
• PSSALRE
• Serine/threonine-protein kinase PSSALRE
• Tau protein kinase II catalytic subunit
• TPKII catalytic subunit

Background

Principal Names: Cyclin-dependent kinase 5 Official Gene Symbol: CDK5 Gene ID: 1020 (Human) Gene Map Locus: 7q36 (Human). Cdk5 is a proline-directed serine/threonine kinase, belonging to the cyclin-dependant kinase family. It is primarily expressed in terminally differentiated cells, such as neurons, muscle and len fibres. Association of Cdk5 with a neuron-specific regulatory subunit, p35, is required for its kinase activation. The complex of Cdk5 and p35, plays important roles in brain development, such as neuronal migration and neurite outgrowth. The protein is a downstream effector of Rac, a member of the Rho family of small GTPases, which regulates neuronal growth cone motility and the cytoskeletal rearrangements involved in cell migration and ruffling. It also plays a role in regulating both cell-matrix and cell-cell interactions in the non-neuronal cells like len fibres. The pathological role of Cdk5 has been observed in Alzheimer's disease where it promotes neurodegeneration by aberrant hyperphosphorylation of Tau protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDK5