CDC73/HRPT2 Antibody

Product Discontinued

CDC73/HRPT2 Antibody Summary

• Immunogen: A synthetic peptide which maps to a region between residues 375 and 425 of human Parafibromin using the numbering given in TrEMBL entry Q6P1J9 (GeneID 79577).
• Specificity: NB200-185 is specific for human Parafibromin protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDC73
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1-4 ug/mg lysate
  • Western Blot 1:10000-1:30000
• Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Prepare working dilution immediately before use.
• Control:

  CDC73/HRPT2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CDC73/HRPT2 Antibody

• C1orf28hyperparathyroidism 2 (with jaw tumor)
• CDC73
• cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S.cerevisiae)
• Cell division cycle protein 73 homolog
• chromosome 1 open reading frame 28
• HPTJT
• HPT-JT
• HRPT2
• HRPT2FLJ23316
• Hyperparathyroidism 2 protein
• HYX
• Parafibromin

Background

Parafibromin, the product of gene HPRT2, acts as a tumor suppressor protein by inhibiting cell proliferation and blocking expression of cyclin D1 when overexpressed. Parafibromin has also been shown to bind with the PAF1 complex / RNA polymerase II which is involved with transcription elongation and the RNA processing pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CDC73/HRPT2 Antibody (NB200-185)(1)

Publication using NB200-185

• Hoffmans R, Basler K. BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Mech Dev 2007-01-01 [PMID: 17113272]

Bioinformatics

• Gene Symbol: CDC73
• Entrez:
  • 79577(Human)
• Uniprot:
  • Q6P1J9()