CD39/ENTPD1 Antibody (495826)

Images

 
Mouse splenocytes were stained with Rat Anti-Mouse CD39/ENTPD1 Monoclonal Antibody (Catalog # MAB4398, filled histogram) or isotype control antibody (Catalog # MAB005, open histogram), followed by ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, IP, CyTOF-ready
Clone
495826
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

CD39/ENTPD1 Antibody (495826) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CD39/ENTPD1
Thr38-Ile478
Accession # AAH11278
Specificity
Detects mouse CD39/ENTPD1 in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant human CD39 is observed and no cross-reactivity with recombinant mouse CD39L3 or recombinant human CD39L4 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
ENTPD1
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunoprecipitation 25 ug/mL
  • CyTOF-ready
Publications
Read Publication using
MAB4398 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD39/ENTPD1 Antibody (495826)

  • ADPase
  • ATPDase
  • ATP-diphosphatase
  • CD39 antigen
  • CD39
  • CD39EC 3.6.1.5
  • DKFZp686D194
  • DKFZp686I093
  • EC 3.6.1
  • ecto-apyrase
  • Ecto-ATP diphosphohydrolase 1
  • Ecto-ATPase 1
  • Ecto-ATPDase 1
  • ectonucleoside triphosphate diphosphohydrolase 1
  • ENTPD1
  • FLJ40921
  • FLJ40959
  • Lymphoid cell activation antigen
  • NTPD1
  • NTPDase 1
  • NTPDase-1

Background

Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase-1) is an integral membrane protein with an extracellular active site. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker (1), but it is also present on the surface of natural killer cells, T cells, and some endothelial cells (2). NTPDase-1 hydrolyzes the beta - and gamma  phosphate residues of nucleotides, preferring ATP as the substrate. Through its hydrolysis of extracellular nucleotides, NTPDase-1 plays a role in the regulation of purinergic signaling (3). NTPDase-1 is involved in the processes of thromboregulation and vascular inflammation (4). The administration of soluble NTPDase-1 may have therapeutic applications for the treatment of some vascular and transplantation-associated diseases (5).

  1. Rowe, M. et al. (1982) Int. J. Cancer 29:373.
  2. Kansas, G.S. et al. (1991) J. Immunol. 146:2235.
  3. Kishore, B.K. et al. (2005) Am. J. Physiol. Renal Physiol. 288:F1032.
  4. Marcus, A.J. et al. (2005) Semin. Thromb. Hemost. 31:234.
  5. Robson, S.C. et al. (2005) Semin. Thromb. Hemost. 31:217.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: WB, Flow, IP, CyTOF-ready

Publications for CD39/ENTPD1 Antibody (MAB4398)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-Fr.


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(1)
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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB4398U
Alexa Fluor 405 FAB4398V
Alexa Fluor 488 FAB4398G
Alexa Fluor 594 FAB4398T
Alexa Fluor 647 FAB4398R
Alexa Fluor 700 FAB4398N
Alexa Fluor 750 FAB4398S
Allophycocyanin FAB4398A

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Bioinformatics Tool for CD39/ENTPD1 Antibody (MAB4398)

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Bioinformatics

Gene Symbol ENTPD1
Uniprot