CCM2 Antibody

Western Blot: CCM2 Antibody [H00083605-B01P] - Analysis of CCM2 expression in human placenta.

Western Blot: CCM2 Antibody [H00083605-B01P] - Analysis of CCM2 expression in transfected 293T cell line by CCM2 polyclonal antibody. Lane 1: CCM2 transfected lysate(48.84 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

CCM2 Antibody Summary

• Immunogen: CCM2 (NP_113631.1, 1 a.a. - 444 a.a.) full-length human protein. MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
• Specificity: CCM2 - cerebral cavernous malformation 2,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: CCM2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Application Notes: Antibody reactive against transfected lysate and tissue lysate for Western Blot. Has also been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CCM2 Antibody

• C7orf22OSM
• cerebral cavernous malformation 2
• Cerebral cavernous malformations 2 protein
• chromosome 7 open reading frame 22
• malcavernin
• MGC4067
• MGC4607
• MGC74868

Background

p16 INK4a is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCM2
• Entrez:
  • 83605(Human)
• Uniprot:
  • NP_113631.1(Human)