Catenin alpha 2 Antibody

Product Discontinued

Catenin alpha 2 Antibody Summary

• Immunogen: Synthetic peptide: DLANRFKEFGKKMVKL conjugated to KLH, corresponding to amino acids 171-186 of Human alpha 2 Catenin.
• Localization: Cytoplasmic
• Specificity: Anti-alpha-N-Catenin recognizes alpha-N-catenin (102 kDa) by immunoblotting.Staining of the alpha-N-catenin band in immunoblotting is specifically inhibited with the alpha-N-catenin immunizing peptide (human, amino acids 171-186).
• Predicted Species: Mouse (93%), Chicken (93%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CTNNA2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000
• Application Notes: Detects a band of approximately 102 kDa.
• Control:

  Catenin alpha 2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 10mM PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: IgG purified

Alternate Names for Catenin alpha 2 Antibody

• Alpha-catenin-related protein
• cancer/testis antigen 114
• CAPRrelated
• catenin (cadherin-associated protein), alpha 2
• catenin alpha-2
• CTNR
• DKFZp686H02198

Background

It has been shown that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. Results suggest that alpha N-catenin is a key regulator for the stability of synaptic contacts (1). We show here that antibodies against alpha catenin also immunoprecipitate complexes that contain human N-cadherin, mouse P-cadherin, chicken A-CAM (adherens junction-specific CAM; also called N-cadherin) or Xenopus U-cadherin, demonstrating that alpha catenin is complexed with other cadherins(2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CTNNA2
• Entrez:
  • 1496(Human)