CARD11/CARMA1 Antibody Pack

Product Discontinued

CARD11/CARMA1 Antibody Pack Summary

• Immunogen: See individual datasheets.
• Specificity: NP_115791
• Gene: CARD11

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:100-1:2000

Reactivity Notes

Human and predicted to react with Mouse and Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.

Alternate Names for CARD11/CARMA1 Antibody Pack

• BIMP3
• BIMP3card-maguk protein 1
• CARD11
• CARD-containing MAGUK protein 1
• Carma 1
• CARMA1
• CARMA1bcl10-interacting maguk protein 3
• caspase recruitment domain family, member 11
• caspase recruitment domain-containing protein 11
• MGC133069

Background

CARMA1 is a 1154 amino acid protein playing a major role in the activation of NF-kappa-B through BCL10 and IKK. It contains a caspase-associated recruitment domain (CARD) and is thus included in the CARD protein family, a guanylate kinase-like domain and a PDZ (DHR) domain. The domain structure is similar to that of CARD14 protein and belongs to a class of proteins known as the membrane-associated guanylate kinase (MAGUK) family acting as molecular scaffolds. Binding of CARD11 and BCL10, a positive regulator of cell apoptosis and NF-kappaB activation, to each other occurs by CARD-CARD interaction and it stimulates the phosphorylation of BCL10. CARMA1 is detected in adult peripheral blood leukocytes, thymus, spleen and liver and in some cell lines except in HeLa S3, Molt-4, A549 and G431 cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CARD11