Carboxylesterase 2/CES2 Antibody (861429) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 861429
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Carboxylesterase 2/CES2 Antibody (861429) [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Carboxylesterase 2/CES2
  Gln27-Leu559
  Accession # O00748
• Specificity: Detects human Carboxylesterase/CES2 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Carboxylesterase 2/CES2 Antibody (861429) [Alexa Fluor® 647]

• carboxylesterase 2 (intestine, liver)
• Carboxylesterase 2
• carboxylesterase 2EC 3.1.1.1
• CE-2
• CE-2PCE-2
• CES2
• CES2A1
• EC 3.1.1
• EC 3.1.1.84
• hCE-2
• iCE
• intestinal carboxylesterase; liver carboxylesterase-2
• PCE-2

Background

Carboxylesterase 2 is a member of a serine esterase family composed of enzymes which hydrolyze ester and amide bonds (1, 2). The members in this family share the serine hydrolase fold observed in other esterases (3). They have broad substrate specificity from small molecule esters such as phenylester to long-chain fatty acid esters and thioesters. They play a major role in the pharmacokinetics of most therapeutic agents containing an ester. By de-esterification, they can activate or inactivate the agents. They also participate in the detoxification of drugs such as cocaine and heroin in serum and liver. In addition to narcotics, they can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents, such as malathion, sarin, tabun, and VX. In addition to the hydrolytic activity, they can perform transesterification. This reaction is important for cholesterol homeostasis. Three major human CESs have been identified (4). CES1 is highly expressed in liver. CES2 is present in the small intestine, colon, kidney, liver, heart, brain, and testis. CES3 is brain-specific. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.