CALHM1 Antibody

Images

 
Western Blot: CALHM1 Antibody [NBP1-77112] - Rat liver tissue lysate at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry-Paraffin: CALHM1 Antibody [NBP1-77112] - Rat liver tissue with CALHM1 antibody at 5 ug/mL.
Immunofluorescence: CALHM1 Antibody [NBP1-77112] - Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CALHM1 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1. The immunogen is located within amino acids 60 - 110 of CALHM1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CALHM1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence 20 ug/ml
Control Peptide
CALHM1 Peptide (NBP1-77112PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CALHM1 Antibody

  • calcium homeostasis modulator 1
  • FAM26Ccalcium homeostasis modulator protein 1
  • family with sequence similarity 26, member C
  • MGC39514
  • MGC39617
  • Protein FAM26C

Background

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for CALHM1 Antibody (NBP1-77112)

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Bioinformatics

Gene Symbol CALHM1
Uniprot