A portion of amino acids 1-50 of human GPR77 was used as the immunogen.
The amino acid sequence used as immunogen is 100% homologous in human, and chimp (isoforms 1, 2, 3, and 4), 88% homologous in rhesus monkey (isoforms 1, 2, 3), and 76% homologous in bovine (isoforms 1 and 2).
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Cross reacts with Chimpanzee and Human. Predicted to react with Bovine and Rhesus Monkey.
Alternate Names for C5L2/GPR77 Antibody
C5a anaphylatoxin chemotactic receptor C5L2
C5L2G-protein coupled receptor 77
G protein-coupled receptor 77
G protein-coupled receptor C5L2
Official Gene Symbol: GPR77 Gen Bank Accession Number: NP_060955 Gene ID: 27202 (human) Gene Map Locus: 19q13.33 (human) C5L2 is 337A.A orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils/macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.