C4.4A/LYPD3 Antibody [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 532

C4.4A/LYPD3 Antibody [Alexa Fluor® 532] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human C4.4A/LYPD3
  Leu31-His286
  Accession # O95274
• Specificity: Detects human C4.4A/LYPD3 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for C4.4A/LYPD3 Antibody [Alexa Fluor® 532]

• C4.4A
• C4.4A2310061G07Rik
• GPI-anchored metastasis-associated protein C4.4A homolog
• GPI-anchored metastasis-associated protein homolog
• LY6/PLAUR domain containing 3
• ly6/PLAUR domain-containing protein 3
• LYPD3
• Matrigel-induced gene C4 protein
• MIG-C4

Background

LYPD3 (Ly6/PLAUR-domain containing protein 3; also MIG-C4 and GPI anchored metastasis-associated protein C4.4A) is an 85-95 kDa, variably glycosylated member of the Ly6 family of GPI anchored proteins. It is expressed on transitional epithelium, keratinocytes and monocytes, and binds laminin 1 and 5, plus Galectin-3. LYPD3 is believed to support cell migration. Mature human LYPD3 is a 296 amino acid (aa) GPI linked glycoprotein. It contains two UPAR domains (aa 33-126 and 140-222), and an ADAM cleavage site (aa 312-325). The molecule shows extensive N and O linked glycosylation. There is one potential isoform that shows a deletion of aa 129-180. Over aa 31-286, human LYPD3 shares 81% aa identity with mouse LYPD3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O95274(Human)