ELISA: Human c-jun ELISA Kit (Colorimetric) [NBP2-75279] - Samples were spiked with high concentrations of Human c-jun and diluted with Reference Standard & Sample Diluent to produce samples with values within the range ...read more
ELISA: Human c-jun ELISA Kit (Colorimetric) [NBP2-75279] - Standard Curve Reference
Storage of components varies. See protocol for specific instructions.
Kit Components
Components
Biotinylated Detection Ab Diluent
Concentrated Biotinylated Detection Ab (100x)
Concentrated HRP Conjugate (100x)
Concentrated Wash Buffer (25x)
HRP Conjugate Diluent
Micro ELISA Plate (Dismountable)
Plate Sealer
Product Manual
Reference Standard
Sample Diluent
Stop Solution
Substrate Reagent
Alternate Names for Human c-jun ELISA Kit (Colorimetric)
Activator protein 1
AP1
AP-1
cJun
c-Jun
enhancer-binding protein AP1
Jun activation domain binding protein
jun oncogene
jun proto-oncogene
JUN
Proto-oncogene c-Jun
transcription factor AP-1
V-jun avian sarcoma virus 17 oncogene homologp39
v-jun sarcoma virus 17 oncogene homolog (avian)
v-jun sarcoma virus 17 oncogene homolog
Background
The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.