Breast carcinoma amplified sequence 3 Antibody

Images

 
Western Blot: Breast carcinoma amplified sequence 3 Antibody [NBP1-77125] - Rat brain tissue lysate with BCAS3 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry-Paraffin: Breast carcinoma amplified sequence 3 Antibody [NBP1-77125] - Human breast carcinoma with BCAS3 antibody at 5 ug/mL.
Immunofluorescence: Breast carcinoma amplified sequence 3 Antibody [NBP1-77125] - Human breast carcinoma tissue at 20 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Breast carcinoma amplified sequence 3 Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human BCAS3. The immunogen is located within amino acids 50 - 100 of BCAS3.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BCAS3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunofluorescence 20 ug/ml
Control Peptide
Breast carcinoma amplified sequence 3 Peptide (NBP1-77125PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Breast carcinoma amplified sequence 3 Antibody

  • BCAS4/BCAS3 fusion
  • breast carcinoma amplified sequence 3
  • breast carcinoma amplified sequence 4/3 fusion protein
  • breast carcinoma-amplified sequence 3
  • DKFZp686O1527
  • FLJ20128
  • GAOB1
  • MAAB
  • metastasis associated antigen of breast cancer
  • MGC4973
  • protein Maab1

Background

The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol BCAS3
Uniprot