Breast carcinoma amplified sequence 3 Antibody - BSA Free

Western Blot: Breast carcinoma amplified sequence 3 Antibody [NBP1-77125] - Rat brain tissue lysate with BCAS3 antibody at (A) 0.5 and (B) 1 ug/ml.

Immunocytochemistry/ Immunofluorescence: Breast carcinoma amplified sequence 3 Antibody - BSA Free [NBP1-77125] - Immunofluorescence of Breast carcinoma amplified sequence 3 in human breast carcinoma tissue with Breast carcinoma amplified sequence 3 antibody at 20 u/mL.

Immunohistochemistry: Breast carcinoma amplified sequence 3 Antibody - BSA Free [NBP1-77125] - Immunohistochemistry of Breast carcinoma amplified sequence 3 in human breast carcinoma with Breast carcinoma amplified sequence 3 antibody at 5 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Breast carcinoma amplified sequence 3 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Breast carcinoma amplified sequence 3 Antibody - BSA Free (NBP1-77125) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human BCAS3. The immunogen is located within amino acids 50 - 100 of BCAS3. Amino Acid Squence: FENADLNDTSRNLEFHEI
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BCAS3
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 0.5-1 ug/ml
• Control Peptide:

  Breast carcinoma amplified sequence 3 Peptide (NBP1-77125PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for Breast carcinoma amplified sequence 3 Antibody - BSA Free

• BCAS4/BCAS3 fusion
• breast carcinoma amplified sequence 3
• breast carcinoma amplified sequence 4/3 fusion protein
• breast carcinoma-amplified sequence 3
• DKFZp686O1527
• FLJ20128
• GAOB1
• MAAB
• metastasis associated antigen of breast cancer
• MGC4973
• protein Maab1

Background

The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCAS3
• Uniprot:
  • EAW51415(Human)