BMPR-II Antibody [DyLight 680]

• Reactivity: Hu
• Applications: Flow, IHC, CyTOF-ready
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 680

BMPR-II Antibody [DyLight 680] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human BMPR-II
  Ala26-Ile151
  Accession # Q13873
• Specificity: Detects human BMPR-II in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: BMPR2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for BMPR-II Antibody [DyLight 680]

• BMP type II receptor
• BMP type-2 receptor
• BMPR2
• BMPR-2
• BMPR3
• BMPRII
• BMPR-II
• BMPR-IIprimary pulmonary hypertension 1
• Bone morphogenetic protein receptor type II
• bone morphogenetic protein receptor type-2
• bone morphogenetic protein receptor, type II (serine/threonine kinase)
• BRK-3
• EC 2.7.11
• EC 2.7.11.30
• FLJ41585
• FLJ76945
• PPH1BMR2
• T-ALK
• type II activin receptor-like kinase
• type II receptor for bone morphogenetic protein-4

Background

BMPR2 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BMPR2