Blooms Syndrome Protein Blm [p Thr99] Antibody [HRP]

Product Discontinued

Blooms Syndrome Protein Blm [p Thr99] Antibody [HRP] Summary

• Immunogen: Synthetic phospho-peptide surrounding the Blooms Syndrome Protein Blm Threonine 99 region [UniProt# P54132]
• Modification: p Thr99
• Localization: Nuclear
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BLM
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: This Blooms Syndrome Protein Blm [phospho Thr99] is useful in Western blot where a band can be seen at ~160 kDa. Immunocytochemistry/Immunofluorescence was reported in scientific literature.
  
  The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Readout System:
  • NovaLume Plus Chemiluminescent Reagent LUM-555

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for Blooms Syndrome Protein Blm [p Thr99] Antibody [HRP]

• BLM
• Bloom syndrome
• Bloom syndrome, RecQ helicase-like
• Blooms Syndrome Protein Blm
• BSBloom syndrome protein
• DNA helicase, RecQ-like type 2
• EC 3.6.1
• EC 3.6.4.12
• MGC126616
• MGC131618
• RecQ protein-like 3
• RecQ2
• RECQ2MGC131620
• RECQL3
• RECQL3RECQL2

Background

Blooms Syndrome Protein Blm is a member of the RecQ helicase protein family. The protein contains 1417 amino acids; including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. Blooms Syndrome Protein Blm is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. This gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BLM