BLNK Antibody

Western Blot: BLNK Antibody [H00029760-D01P] - Analysis of BLNK expression in PC-12.

Western Blot: BLNK Antibody [H00029760-D01P] - Analysis of BLNK expression in transfected 293T cell line by BLNK polyclonal antibody.Lane 1: BLNK transfected lysate(50.50 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

BLNK Antibody Summary

• Immunogen: BLNK (AAH18906.1, 1 a.a. - 456 a.a.) full-length human protein. MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEQQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPASPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPIPAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKRVYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLKYAVKVS
• Specificity: Reacts with B-cell linker.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BLNK
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is reactive against transfected lysate in western blot, and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for BLNK Antibody

• AGM4
• B cell linker protein
• BASH
• B-cell adapter containing a SH2 domain protein
• B-cell adapter containing a Src homology 2 domain protein
• B-cell linker protein
• B-cell linker
• BLNK
• BLNK-s
• Cytoplasmic adapter protein
• Ly57
• MGC111051
• SLP65
• SLP-65BLNK-S
• SLP65Ly57
• Src homology 2 domain-containing leukocyte protein of 65 kDa

Background

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BLNK
• Entrez:
  • 29760(Human)
• Uniprot:
  • AAH18906.1(Human)