beta-Defensin 3 Antibody [HRP]

• Reactivity: Hu, Rt, Po, Ca
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: HRP

beta-Defensin 3 Antibody [HRP] Summary

• Immunogen: A synthetic peptide made to an internal portion of Defensin beta 3 (between amino acids 10-60) [UniProt P81534]
• Predicted Species: Porcine (90%), Canine (90%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DEFB103B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human and rat reactivity reported in (PMID: 21369366).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for beta-Defensin 3 Antibody [HRP]

• BD14
• BD3
• BD-3
• beta-defensin 103
• betaDefensin 3
• beta-Defensin 3
• DEFB103
• DEFB103A
• DEFB103B
• DEFB3
• DEFB-3
• DEFB3DEFB103A
• Defensin, beta 103
• defensin, beta 103B
• Defensin-like protein
• HBD-3
• HBD3HBP3

Background

Defensin beta 3 is a novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and clones from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomyosin-resistant Entoerococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3, therefore, might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DEFB103B