beta-Defensin 3 Products

Description

Defensin beta 3 is a novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and clones from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomyosin-resistant Entoerococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3, therefore, might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.

Bioinformatics

Product By Gene ID	55894
Alternate Names	BD14 BD3 BD-3 beta-defensin 103 betaDefensin 3 beta-Defensin 3 DEFB103 DEFB103A DEFB103B DEFB3 DEFB-3 DEFB3DEFB103A Defensin, beta 103 defensin, beta 103B Defensin-like protein HBD-3 HBD3HBP3

Research Areas for beta-Defensin 3

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Biologically Active Proteins
Immunology

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Beta-defensin-3: I may be small but I'm powerful! Beta-defensin 3 is a novel, non-hemolytic antimicrobial cationic peptide originally isolated from human lesional psoriatic scales and keratinocyte clones. It is a very small (2-6 kD) yet potent salt-insensitive broad spectrum antimicrobial that ta...    Read more.

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