beta-Defensin 3 Antibody [DyLight 488]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 488

beta-Defensin 3 Antibody [DyLight 488] Summary

• Immunogen: E. coli-derived recombinant human beta -Defensin 3
  Gly23-Lys67
  Accession # P81534
• Specificity: Detects human beta -Defensin 3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human beta -Defensin 2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: DEFB103B
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for beta-Defensin 3 Antibody [DyLight 488]

• BD14
• BD3
• BD-3
• beta-defensin 103
• betaDefensin 3
• beta-Defensin 3
• DEFB103
• DEFB103A
• DEFB103B
• DEFB3
• DEFB-3
• DEFB3DEFB103A
• Defensin, beta 103
• defensin, beta 103B
• Defensin-like protein
• HBD-3
• HBD3HBP3

Background

Defensin beta 3 is a novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and clones from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomyosin-resistant Entoerococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3, therefore, might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DEFB103B