Bcl-6 Antibody [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

Bcl-6 Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant mouse Bcl-6
  Glu522-Thr696
  Accession # Q8CB25
• Specificity: Detects human and mouse Bcl-6 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Bcl-6 Antibody [Alexa Fluor® 350]

• B-cell CLL/lymphoma 6
• B-cell lymphoma 6 protein transcript
• Bcl-5
• BCL5B-cell lymphoma 5 protein
• Bcl6
• Bcl-6
• BCL6A
• cys-his2 zinc finger transcription factor
• LAZ3
• LAZ3ZBTB27B-cell lymphoma 6 protein
• lymphoma-associated zinc finger gene on chromosome 3
• Protein LAZ-3
• ZBTB27
• Zinc finger and BTB domain-containing protein 27
• Zinc finger protein 51ZNF51
• zinc finger transcription factor BCL6S
• ZNF51

Background

Bcl-6 (B-cell lymphoma protein 6; also ZFP51, LAZ-3 and Bcl-5) is an 80 kDa member of the Kruppel-like family of zinc finger proteins. It is expressed in germinal center B cells, neutrophils, monocytes, and immature dendritic cells, and serves as a potent transcriptional repressor of genes such as p53. Human Bcl-6 is 706 amino acids (aa) in length and contains an N-terminal BTB/POZ protein interaction domain (aa 32‑99) and a series of six C2H2-type C-terminal zinc finger domains that bind DNA (aa 518‑681). Centrally located are three PEST sequences (aa 336‑430) that undergo phosphorylation by MAPK. This increases the molecular weight of Bcl-6 to 97 kDa and induces its degradation. Human Bcl-6 is about 99% aa identical to mouse and canine Bcl-6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.