BAI2 Antibody (2528B) [Alexa Fluor™ Plus 555]

• Clone: 2528B
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 555

BAI2 Antibody (2528B) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human BAI2 in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BAI2 Antibody (2528B) [Alexa Fluor™ Plus 555]

• BAI2
• brain-specific angiogenesis inhibitor 2
• Brain-specific angiongenesis inhibitor-2

Background

Brain angiogenesis inhibitor 2 (BAI2), along with BAI1 and BAI3, form a subfamily of brain specific adhesion GPCRs. They are large, glycosylated molecules, approximately 180-220 kDa, and play a role in neuronal synapse formation and maintenance. Mature human BAI2 consists of a 903 amino acid (aa) N-terminal extracellular domain (ECD) containing four TSP1 domains, a hormone binding domain (HBD), a GAIN domain and a GPS protease sensitive linker, followed by a region with seven transmembrane segments and a 410 aa C-terminal cytoplasmic domain (1). Within the N-terminal ECD, human BAI2 shares 96% aa sequence identity with both mouse and rat BAI2. BAI2 is expressed primarily in neurons and astrocytes of the hippocampus and cerebral cortex in the brain (2, 3). To become functional, BAI2 might require activation by cleavage at the GPS domain (4). BAI family members are known to bind the C1q-like complement (C1qL) family via thrombospondin type 1 repeats (TSRs) which are conserved between BAI members (5). BAI2 has been shown to suppress expression of VEGF leading to increased neurogenesis in the dentate gyrus of the hippocampus (6).

1. Duman, J.G. et al. (2016) Neural Plast. 2016:8301737.
2. Shiratsuchi, T. et al. (1997) Cytogenet. Cell Genet. 79:103.
3. Kee, H.J. et al. (2002) J. Cereb. Blood Flow Metab. 22:1054.
4. Daisuke, O. et al. (2010) J. Recept Signal Transduct Res 30:143.
5. Bolliger, M.F. et al. (2011) Proc. Natl. Acad. Sci. USA 108:2534.
6. Jeong, B.C. et al. (2016) FEBS Lett 580:669.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.