Attractin Antibody

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Immunohistochemistry-Paraffin: Attractin Antibody [NB100-58757] - ATRN / Attractin antibody (20 ug/ml) was used to stain formalin-fixed, paraffin-embedded human spleen, followed by biotinylated goat anti-rabbit IgG ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.7 mg/ml

Order Details

Attractin Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from internal region of human ATRN / Attractin.
Epitope
internal domain of human protein
Specificity
Human ATRN / Attractin. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCTD19 (50%).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ATRN
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10 - 1:500

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Monkey (88%), Bovine (88%), Porcine (88%), Marmoset (81%), Rat (81%), Bat (81%), Hamster (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
0.7 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Attractin Antibody

  • ATRN
  • Attractin
  • DPPT-L
  • KIAA0548
  • Mahogany Protein
  • MGC126754
  • MGCA

Background

Attractin is a serum glycoprotein of 175 kDaand found in both membrane-bound and secreted forms as a result of alternative splicing. Both the secreted and membrane-bound forms of attractin may be involved in the development and maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes and modulates interactions between T cells and monocytes/macrophages, was examined as a potential marker of immune activity. Attractinmay be a component of a pathway for regulated protein turnover that also involves mahogunin, a wide-expressed E3 ubiquitinligase found at particularly high levels in the brain. Attractinwas considered as an extracellular target amenable for the development of obesity-regulating drugs, also.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ATRN
Entrez