ATP2C2 Antibody

Images

 
Western Blot: ATP2C2 Antibody [NBP1-76567] - 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide
Immunocytochemistry/ Immunofluorescence: ATP2C2 Antibody [NBP1-76567] - Immunofluorescence of ATP2C2 in 3T3 cells with ATP2C2 antibody at 20 ug/mL.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ATP2C2 Antibody Summary

Immunogen
Antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP2C2. The immunogen is located within the first 50 amino acids of ATP2C2.
Specificity
At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ATP2C2
Purity
Peptide affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
Control Peptide
Reviewed Applications
Read 2 Reviews rated 3
using
NBP1-76567 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for ATP2C2 Antibody

  • ATPase 2C2
  • ATPase, Ca++ transporting, type 2C, member 2
  • calcium-transporting ATPase type 2C member 2
  • DKFZp686H22230
  • KIAA0703
  • secretory pathway Ca(2+)-ATPase 2
  • secretory pathway calcium ATPase 2
  • SPCA2

Background

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Reviews for ATP2C2 Antibody (NBP1-76567) (2) 32

Average Rating: 3
(Based on 2 reviews)
We have 2 reviews tested in 1 species: Human.

Reviews using NBP1-76567:
Filter by Applications
ICC
(1)
WB
(1)
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Human
(2)
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Images Ratings Applications Species Date Details
Immunocytochemistry ATP2C2 NBP1-76567
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reviewed by:
Scott Messenger
ICC Human 12/15/2017
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Summary

ApplicationImmunocytochemistry
Sample TestedLS180 human colorectal adenocarcinoma cell line
SpeciesHuman
Lot6289-1101
Western Blot ATP2C2 NBP1-76567
Enlarge
reviewed by:
Scott Messenger
WB Human 12/15/2017
View

Summary

ApplicationWestern Blot
Sample TestedLS180 human colorectal adenocarcinoma cell line
SpeciesHuman
Lot6289-1101

Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for ATP2C2 Antibody (NBP1-76567) (0)

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Secondary Antibodies

 

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Recent Reviews

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Scott Messenger
12/15/2017
Application: ICC
Species: Human

Scott Messenger
12/15/2017
Application: WB
Species: Human

Bioinformatics

Gene Symbol ATP2C2
Uniprot