ARMER Antibody - BSA Free

Western Blot: ARMER Antibody - BSA Free [NBP3-47950] - Mouse lung tissue were subjected to SDS PAGE followed by western blot with (ARMER antibody) at dilution of 1:300

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

ARMER Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit ARMER Antibody - BSA Free (NBP3-47950) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: ADP-ribosylation factor-like 6 interacting protein 1. (Uniprot# Q15041)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ARL6IP1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500-1:1000
• Application Notes: Theoretical Molecular Weight is 22-24 kDa

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ARMER Antibody - BSA Free

• ADP-ribosylation factor-like 6 interacting protein 1
• ADP-ribosylation factor-like 6 interacting protein
• AIP1
• Aip-1
• apoptotic regulator in the membrane of the endoplasmic reticulum
• ARL-6-interacting protein 1
• ARL6IPaip-1
• ARMER
• KIAA0069ADP-ribosylation factor-like protein 6-interacting protein 1

Background

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ARL6IP1