ARHGEF6 Antibody - Azide and BSA Free

Western Blot: ARHGEF6 Antibody [H00009459-B01P] - Analysis of ARHGEF6 expression in transfected 293T cell line by ARHGEF6 polyclonal antibody. Lane 1: ARHGEF6 transfected lysate(85.36 KDa). Lane 2: Non-transfected lysate.

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

ARHGEF6 Antibody - Azide and BSA Free Summary

• Immunogen: ARHGEF6 (NP_004831, 1 a.a. - 776 a.a.) full-length human protein. MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
• Specificity: ARHGEF6 - Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: ARHGEF6
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Application Notes: Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ARHGEF6 Antibody - Azide and BSA Free

• alphaPIX
• Alpha-Pix
• COOL-2
• COOL2alpha
• KIAA0006Cool2
• mental retardation, X-linked 46
• MRX46
• PAK-interacting exchange factor alpha
• PIXA
• Rac/Cdc42 guanine exchange factor (GEF) 6
• Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
• Rac/Cdc42 guanine nucleotide exchange factor 6
• rho guanine nucleotide exchange factor 6

Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ARHGEF6 Antibody (H00009459-B01P)(1)

Publication using H00009459-B01P

• KlAmbt V, Buerger F, Wang C et al. Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs Journal of the American Society of Nephrology : JASN 2022-11-22 [PMID: 36414417] (ELISA, WB, Mouse)

Bioinformatics

• Gene Symbol: ARHGEF6
• Entrez:
  • 9459(Human)
• Uniprot:
  • NP_004831(Human)