ARHGEF3 Antibody - Azide and BSA Free

Western Blot: ARHGEF3 Antibody [H00050650-B01P] - Analysis of ARHGEF3 expression in transfected 293T cell line by ARHGEF3 polyclonal antibody. Lane 1: ARHGEF3 transfected lysate(35.64 KDa). Lane 2: Non-transfected lysate.

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

ARHGEF3 Antibody - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse ARHGEF3 Antibody - Azide and BSA Free (H00050650-B01P) is a polyclonal antibody validated for use in WB. Anti-ARHGEF3 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: ARHGEF3 (AAH99715, 1 a.a. - 324 a.a.) full-length human protein. MKLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVVCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV
• Specificity: ARHGEF3 - Rho guanine nucleotide exchange factor (GEF) 3,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: ARHGEF3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Application Notes: Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ARHGEF3 Antibody - Azide and BSA Free

• DKFZP434F2429
• Exchange factor found in platelets and leukemic and neuronal tissues
• FLJ98126
• MGC118905
• Rho guanine nucleotide exchange factor (GEF) 3
• rho guanine nucleotide exchange factor 3,59.8 kDA protein
• RhoGEF protein
• XPLNXPLN

Background

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ARHGEF3 Antibody (H00050650-B01P)(1)

Publication using H00050650-B01P

• Kamio K, Azuma A, Usuki J et al. XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts. Pulm Pharmacol Ther 2017-03-14 [PMID: 28315487]

Bioinformatics

• Gene Symbol: ARHGEF3
• Entrez:
  • 50650(Human)
• Uniprot:
  • AAH99715(Human)