ARHGEF3 Products

Description

ARHGEF3, also known as Rho guanine nucleotide exchange factor 3, is a 526 amino acid protein that functions when extracellular interactions activate G coupled protein receptors through conversion of GTP into GDP, by increasing GTPase activity specifically Rho GTPases, which in turn has been shown to have a strong role in bone cells specifically with bone mineral density (BMD). Studies of ARHGEF3 are being done on the following diseases and disorders, hypochromic anemia, osteoporosis, neuronitis, leukemia, arthritis, and spasticity. This protein has interactions with RHOA, RHOB, SHC1, and CDC42 in the G-protein signaling pathways of both RhoA and RhoB, cell death signaling via NRAGE, NRIF and NADE, as well as the interferon pathway.

Bioinformatics

Entrez	50650 Human 71704 Mouse
Uniprot	AAH99715 Human AAH99715.1 Human NM_019555 Human NP_062455 Human Q9NR81 Human
Product By Gene ID	50650
Alternate Names	DKFZp434F2429 DKFZP434F2429 Exchange factor found in platelets and leukemic and neuronal tissues FLJ98126 MGC118905 Rho guanine nucleotide exchange factor (GEF) 3 rho guanine nucleotide exchange factor 3,59.8 kDA protein RhoGEF protein XPLNXPLN

Research Areas for ARHGEF3

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Signal Transduction