Aquaporin-4 Antibody (1093722) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 1093722
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

Aquaporin-4 Antibody (1093722) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects a synthetic peptide specific for human Aquaporin-4 around aa 315 in Direct ELISA.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Aquaporin-4 Antibody (1093722) [Alexa Fluor™ Plus 555]

• AQP4
• AQP-4
• Aquaporin 4
• MGC22454
• MIWC
• WCH4

Background

Aquaporin 4, AQP4, is a 35kDa water channel protein that plays an important role in brain water homeostasis.  AQP4 is highly expressed in the end feet of astrocytes in the brain and CNS with the largest presence in the cerebellum and spinal cord grey matter.  It can also be located in epithelial cells of many organs throughout the body.  The main function of AQP4 is to provide fast water transportation and homeostatic balance throughout the central nervous system.

1. Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P. Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13052-6. doi: 10.1073/pnas.91.26.13052. PMID: 7528931; PMCID: PMC45579. 
2. Halsey AM, Conner AC, Bill RM, Logan A, Ahmed Z. Aquaporins and Their Regulation after Spinal Cord Injury. Cells. 2018 Oct 18;7(10):174. doi: 10.3390/cells7100174. PMID: 30340399; PMCID: PMC6210264. 
3. Verkman AS, Phuan PW, Asavapanumas N, Tradtrantip L. Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO. Brain Pathol. 2013 Nov;23(6):684-95. doi: 10.1111/bpa.12085. PMID: 24118484; PMCID: PMC3890327. 
4. Gleiser C, Wagner A, Fallier-Becker P, Wolburg H, Hirt B, Mack AF. Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs-A Comparative Perspective. Int J Mol Sci. 2016 Aug 26;17(9):1411. doi: 10.3390/ijms17091411. PMID: 27571065; PMCID: PMC5037691.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.