APLP-2 Antibody [Alexa Fluor® 594]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 594

APLP-2 Antibody [Alexa Fluor® 594] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse APLP-2
  Leu37-Ser624
  Accession # AAH52396.2
• Specificity: Detects mouse APLP-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) APLP-2 is observed and less than 1% cross-reactivity with rhAPLP-1 and recombinant mouse APLP-1 is observed
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for APLP-2 Antibody [Alexa Fluor® 594]

• amyloid beta (A4) precursor-like protein 2
• amyloid precursor protein homolog HSD-2
• Amyloid protein homolog
• amyloid-like protein 2
• APLP2
• APLP-2
• APPH
• APPHCDEI box-binding protein
• APPL2
• CDEBP
• WALPLP2
• YWK-II

Background

Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP family of type I transmembrane (TM) proteins. Its 595 aa extracellular region has multiple domains, including an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, and a membrane proximal linker region that contains a GAG attachment site. Several alternatively spliced APLP-2 isoforms have been reported. APLP-2 is proteolytically cleaved by MMPs and secretases and forms both homodimers and heterodimers with APP and APLP-1. Over the range used as immunogen, mouse APLP-2 shares 97% and 91% aa sequence identity with rat and human ALPL-2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.