APBA1 Antibody

Western Blot: APBA1 Antibody [NBP1-06015] - (0.1ug/ml) staining of Human Brain (Cerebellum) 35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

APBA1 Antibody Summary

• Description: Novus Biologicals Goat APBA1 Antibody (NBP1-06015) is a polyclonal antibody validated for use in WB and ELISA. Anti-APBA1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-EASHPSQDGKRQYK corresponding to internal region according to NP_001154.2.
• Predicted Species: Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: APBA1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
  • Western Blot 0.1 - 0.3 ug/ml
• Application Notes: WB: Approx. 100 kDa band observed in human brain (cerebellum and hippocampus) lysates (calculated MW of 92.9 kDa band according to NP_001154.2).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for APBA1 Antibody

• Adapter protein X11alpha
• amyloid beta (A4) precursor protein-binding, family A, member 1
• amyloid beta A4 precursor protein-binding family A member 1
• D9S411Eadaptor protein X11alpha
• LIN10
• mint-1
• MINT1amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
• Neuronal Munc18-1-interacting protein 1
• Neuron-specific X11 protein
• phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
• UROP11
• X11A
• X11X11ALPHA

Background

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for APBA1 Antibody (NBP1-06015)(1)

Publication using NBP1-06015

• Jacobs EH, Williams RJ, Francis PT. Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease. Neuroscience 2006-01-01 [PMID: 16413130]

Bioinformatics

• Gene Symbol: APBA1
• Entrez:
  • 320(Human)
  • 319924(Mouse)
  • 83589(Rat)
• Uniprot:
  • NP_001154.2(Human)