ANP32A Antibody (RJ1)

Product Discontinued

ANP32A Antibody (RJ1) Summary

• Immunogen: Recombinant human acidic nuclear phosphoprotein 32A.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ANP32A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:200
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:4000
• Application Notes: This antibody is useful in Immunocytochemistry (works on endogenous), Immunoprecipitation (works on endogenous) and Western Blot (works on endogenous).

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for ANP32A Antibody (RJ1)

• acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
• acidic leucine-rich nuclear phosphoprotein 32 family member A
• Acidic nuclear phosphoprotein pp32
• cerebellar leucine rich acidic nuclear protein
• I1PP2A
• inhibitor-1 of protein phosphatase-2A
• LANPPutative HLA-DR-associated protein I
• Leucine-rich acidic nuclear protein
• MAPMC15orf1
• mapmodulin
• PHAP1MGC150373
• PHAPIMGC119787
• Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
• PP32
• putative human HLA class II associated protein I

Background

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ANP32A Antibody (NBP1-97576)(5)

Publications using NBP1-97576

• D Martinvalet et al. Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity 22, 355. 2005-01-01 [PMID: 15780992]
• Z Fan et al. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112, 659. 2003-01-01 [PMID: 12628186]
• Z Fan et al. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat. Immunol. 4, 145. 2003-01-01 [PMID: 12524539]
• Z Fan et al. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22, 2810. 2002-01-01 [PMID: 11909973]
• PJ Beresford et al. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J. Biol. Chem. 276, 43285. 2001-01-01 [PMID: 11555662]

Bioinformatics

• Gene Symbol: ANP32A