alpha-Synuclein Antibody (2E4.)

Images

 
Western Blot: Synuclein-alpha Antibody (2E4) [H00006622-M01] - Analysis of SNCA expression in transfected 293T cell line by SNCA monoclonal antibody (M01), clone 2E4.Lane 1: SNCA transfected lysate(14.5 KDa).Lane 2: ...read more
Immunoprecipitation: Synuclein-alpha Antibody (2E4) [H00006622-M01] - Analysis of SNCA transfected lysate using anti-SNCA monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with SNCA MaxPab rabbit ...read more
ELISA: alpha-Synuclein Antibody (2E4.) [H00006622-M01] - Synuclein-alpha Antibody (2E4) [H00006622-M01] - Detection limit for recombinant GST tagged SNCA is 0.1 ng/ml as a capture antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IP
Clone
2E4.
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

alpha-Synuclein Antibody (2E4.) Summary

Immunogen
SNCA (NP_000336, 31 a.a. - 140 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Localization
Cytoplasm. Membrane. Nucleus. Membrane-bound in dopaminergic neurons. Also found in the nucleus.
Specificity
SNCA - synuclein, alpha (non A4 component of amyloid precursor)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SNCA
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunoprecipitation
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

Quality control test: Antibody Reactive Against Recombinant Protein.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for alpha-Synuclein Antibody (2E4.)

  • alpha-Synuclein
  • Lewy body) 4
  • MGC110988
  • NACP
  • non A-beta component of AD amyloid
  • Non-A beta component of AD amyloid
  • Non-A4 component of amyloid precursor
  • non-A4 component of amyloid
  • PARK1
  • PARK4
  • PD1
  • SNCA
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Synuclein-alpha

Background

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for alpha-Synuclein Antibody (H00006622-M01). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an alpha-Synuclein antibody with an epitope located in the first half (N-terminus) of the protein - preferably a monoclonal antibody. Can you help me with that?
    • Please take a look at NB110-57475. It has been validated for human, rat and mouse and the applications ICC and WB and the epitope it detects is in the N terminal.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SNCA
Entrez
Uniprot