Alpha Actinin 2 Antibody (EA-53)

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Immunohistochemistry-Paraffin: Alpha Actinin 2 Antibody (EA-53) [NBP1-22630] - Human skeletal muscle

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
EA-53
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Alpha Actinin 2 Antibody (EA-53) Summary

Immunogen
Purified rabbit skeletal alpha-actinin.
Localization
Cytoplasmic
Specificity
This antibody is specific for alpha-skeletal muscle and alpha-cardiac actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac muscle but not in non-sarcomeric muscle elements. This antibody shows a wide range of cross reactivity with various mammalian species.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ACTN2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:25-1:50

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Ascites
Preservative
Sodium Azide
Purity
Unpurified

Alternate Names for Alpha Actinin 2 Antibody (EA-53)

  • actinin, alpha 2
  • Alpha-actinin skeletal muscle isoform 2
  • alpha-actinin skeletal muscle
  • alpha-actinin-2
  • CMD1AA
  • F-actin cross-linking protein

Background

Alpha actinins are actin binding proteins that carry out different purposes in different different cell types. Skeletal, cardiac, and smooth muscle isoforms are localized to the Z disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN2 encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. There are several known transcript variants that result from the use of multiple polyA+ sites. ACTN2 has the ability to form both homo- and heterodimers (with ACTN3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ACTN2
Entrez