alpha 1-Microglobulin Antibody - BSA Free

ELISA: alpha 1-Microglobulin Antibody [NB100-62165] - Analysis of HRP conjugate of NB100-62165. Native Human Alpha-1 Microglobulin detected with Sheep anti Human Alpha-1 Microglobulin:HRP

• Reactivity: Hu
• Applications: ELISA, Func
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 5.0 mg/ml

alpha 1-Microglobulin Antibody - BSA Free Summary

• Immunogen: Highly pure human alpha-1-microglobulin, prepared from the urine of patients with chronic renal proteinuria, molecular weight 25-30 kDa
• Localization: Secreted
• Specificity: This antibody recognises human alpha-1-microglobulin. No cross-reactivity is observed with urine albumin, retinol binding protein or beta-2-microglobulin.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: AMBP
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunodiffusion
• Control:

  alpha 1-Microglobulin Overexpression Lysate

Reactivity Notes

Does not react with:Rat

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 5.0 mg/ml
• Purity: Protein G purified

Alternate Names for alpha 1-Microglobulin Antibody - BSA Free

• A1M
• alpha 1Microglobulin
• alpha 1-Microglobulin
• alpha-1-microglobulin/bikunin precursor
• AMBP
• bikunin
• EDC1
• HCP
• HCPcomplex-forming glycoprotein heterogeneous in charge
• HI30
• IATIL
• inter-alpha-trypsin inhibitor light chain
• ITI
• ITIL
• ITILC
• ITILgrowth-inhibiting protein 19
• protein AMBP
• protein HC
• trypstatin
• uristatin
• uronic-acid-rich protein
• UTI

Background

Alpha 1-microglobulin (A1M) is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function. Alpha(1)microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. Bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Interacts with FN1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AMBP
• Entrez:
  • 259(Human)
• Uniprot:
  • P02760(Human)