alpha 1-Microglobulin Antibody

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ELISA: alpha 1-Microglobulin Antibody [NB100-62165] - Analysis of HRP conjugate of NB100-62165. Native Human Alpha-1 Microglobulin detected with Sheep anti Human Alpha-1 Microglobulin:HRP

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, ID
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
5.0 mg/ml

Order Details

alpha 1-Microglobulin Antibody Summary

Immunogen
Highly pure human alpha-1-microglobulin, prepared from the urine of patients with chronic renal proteinuria (molecular weight 25-30 kD).
Localization
Secreted
Specificity
This antibody recognises human alpha-1-microglobulin. No cross-reactivity is observed with urine albumin, retinol binding protein or beta-2-microglobulin.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
AMBP
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunodiffusion
Positive Control
alpha 1-Microglobulin Lysate (NBL1-07495)

Reactivity Notes

Does not react with:Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
5.0 mg/ml
Purity
Protein G purified

Alternate Names for alpha 1-Microglobulin Antibody

  • A1M
  • alpha 1Microglobulin
  • alpha 1-Microglobulin
  • alpha-1-microglobulin/bikunin precursor
  • AMBP
  • bikunin
  • EDC1
  • HCP
  • HCPcomplex-forming glycoprotein heterogeneous in charge
  • HI30
  • IATIL
  • inter-alpha-trypsin inhibitor light chain
  • ITI
  • ITIL
  • ITILC
  • ITILgrowth-inhibiting protein 19
  • protein AMBP
  • protein HC
  • trypstatin
  • uristatin
  • uronic-acid-rich protein
  • UTI

Background

Alpha 1-microglobulin (A1M) is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function. Alpha(1)microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. Bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Interacts with FN1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol AMBP
Entrez
Uniprot

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