alpha 1-Acid Glycoprotein Antibody [Alexa Fluor® 532]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 532

alpha 1-Acid Glycoprotein Antibody [Alexa Fluor® 532] Summary

• Immunogen: Mouse plasma-derived α1‑Acid Glycoprotein
  Accession # P02763
• Specificity: Detects mouse alpha 1‑Acid Glycoprotein in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross‑reactivity with human alpha 1‑Acid Glycoprotein is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for alpha 1-Acid Glycoprotein Antibody [Alexa Fluor® 532]

• AGP 1
• AGP
• AGP1
• AGP1alpha-1-acid glycoprotein 1
• AGPA
• AGP-A
• alpha 1Acid Glycoprotein
• alpha 1-Acid Glycoprotein
• OMD 1
• ORM
• ORM1
• orosomucoid 1
• Orosomucoid
• orosomucoid-1

Background

alpha 1-Acid Glycoprotein (AGP; also OMD/Orosomucoid) is a 40‑46 kDa member of the immunocalin subfamily, lipocalin family of molecules. In mouse, circulating AGP is principally the product of hepatocytes that originates from multiple related genes (AGP-1, -2 & -3 in Mus musculus). Circulating AGP-1 and -2 are both 189 amino acids (aa) in length, the principal sources of protein, and show 83% aa identity; AGP-3 contributes little to the AGP pool. In mouse blood, AGP is normally 200‑400 μg/mL. In response to inflammatory mediators (IL-6; IL-1), its concentration will rise 2 to 10 fold. More importantly, a complex glycosylation pattern will also change, transitioning from modestly branched to highly branched oligosaccharides. This change is reflected in its bioactivity, which has been shown to be a function of carbohydrate branching. AGP is generally considered to be a suppressor of inflammation. Rat and human AGP share only 70% and 47% aa identity with mouse AGP, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.