Aldo-keto Reductase 1B10/AKR1B10 Antibody

Western Blot: Aldo-keto Reductase 1B10/AKR1B10 Antibody [NB100-56423] - Analysis of Aldo-keto Reductase 1B10/AKR1B10 in A) human, B) mouse, and C) rat liver tissue lysate using this antibody at 1 ug/ml.

Product Discontinued

Aldo-keto Reductase 1B10/AKR1B10 Antibody Summary

• Immunogen: A portion of amino acids 100-200 of human AKR1B10 protein were used as the immunogen.
• Specificity: The NCBI accession number for AKR1B10 is EAL24068.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AKR1B10
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/ml
• Control:

  Human Liver Whole Tissue Lysate (Adult Whole Normal)
  Mouse Liver Whole Tissue Lysate (Adult Whole Normal)
  Aldo-keto Reductase 1B10/AKR1B10 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 0.2% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for Aldo-keto Reductase 1B10/AKR1B10 Antibody

• AKR1B10
• AKR1B11
• AKR1B12
• Aldo-keto Reductase 1B10
• aldo-keto reductase family 1 member B10
• aldo-keto reductase family 1, member B10 (aldose reductase)
• aldo-keto reductase family 1, member B11 (aldose reductase-like)
• AldoketoReductase 1B10
• aldose reductase-like 1
• aldose reductase-like peptide
• Aldose reductase-like
• Aldose reductase-related protein
• ALDRLn
• ARL1
• ARL-1SI reductase
• ARP
• EC 1.1.1
• EC 1.1.1.-
• EC 1.1.1.21
• hARP
• HIS
• HSI
• MGC14103
• Small intestine reductase

Background

Official Gene Symbol AKR1B10 Gene ID 57016(Human) Gene Map Locus 7q33(Human) ARK1B10, a 316A.A protein, catalyzes efficient reduction of aliphatic and aromatic aldehydes. It the first cytosolic NADP (H)-dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AKR1B10
• Entrez:
  • 57016(Human)
  • 67861(Mouse)
  • 296972(Rat)
• Uniprot:
  • C9JRZ8(Human)