AKAP13 293T Cell Transient Overexpression Lysate

Product Discontinued

AKAP13 293T Cell Transient Overexpression Lysate Summary

• Description: Quality control test: Transient overexpression cell lysate was tested with Anti-AKAP13 antibody by Western Blots. Plasmid: pCMV-AKAP13 full-length
• Specificity: AKAP13 293T Cell Transient Overexpression Lysate(Denatured)
• Gene: AKAP13

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)

Lysate Details for Array

• Type: 293T Cell Transient Overexpression
• Protein State: Denatured

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for AKAP13 293T Cell Transient Overexpression Lysate

• A kinase (PRKA) anchor protein 13
• AKAP-LbcAKAP-13
• A-kinase anchor protein 13
• A-kinase anchoring protein
• ARHGEF13
• Breast cancer nuclear receptor-binding auxiliary protein
• BRXNon-oncogenic Rho GTPase-specific GTP exchange factor
• c-lbc
• FLJ11952
• FLJ43341
• Guanine nucleotide exchange factor Lbc
• HA-3
• HT31
• Human thyroid-anchoring protein 31
• LBCLBC oncogene
• Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13
• p47
• PROTO-LB
• PROTO-LBC

Background

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: AKAP13