AKAP13 Antibody

Images

 
Western Blot: AKAP13 Antibody [H00011214-B01P] - Analysis of AKAP13 expression in transfected 293T cell line by AKAP13 polyclonal antibody. Lane 1: AKAP13 transfected lysate(116.38 KDa). Lane 2: Non-transfected lysate.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

AKAP13 Antibody Summary

Immunogen
AKAP13 (NP_658913.1, 1 a.a. ~ 1058 a.a) full-length human protein.
Isotype
IgG
Clonality
Polyclonal
Host
Mouse
Gene
AKAP13
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
Application Notes
This antibody is useful for Western Blot

Reactivity Notes

This product is reactive against Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for AKAP13 Antibody

  • A kinase (PRKA) anchor protein 13
  • AKAP-LbcAKAP-13
  • A-kinase anchor protein 13
  • A-kinase anchoring protein
  • ARHGEF13
  • Breast cancer nuclear receptor-binding auxiliary protein
  • BRXNon-oncogenic Rho GTPase-specific GTP exchange factor
  • c-lbc
  • FLJ11952
  • FLJ43341
  • Guanine nucleotide exchange factor Lbc
  • HA-3
  • HT31
  • Human thyroid-anchoring protein 31
  • LBCLBC oncogene
  • Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13
  • p47
  • PROTO-LB
  • PROTO-LBC

Background

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 13, also known as Brx (breast cancer nuclear receptor-binding auxiliary protein), Lbc (lymphoid blast crisis oncogene), HA-3 or Ht31 (human thyroid-anchoring protein 31), functions as a cAMP-dependent scaffold anchor for PKA and also has Rho-GEF activity. It is known to regulate TLR2 signaling, NFkappaB activation, protein kinase D activation and participate in Actin stress fiber formation. Seven isoforms exist for AKAP 13 and, depending on the isoform, it localizes to the cytoplasm, nucleus or cell membrane.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol AKAP13