Adropin Antibody (976401) [Alexa Fluor® 647]

• Reactivity: Hu, Mu
• Applications: IHC, ICC/IF
• Clone: 976401
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Adropin Antibody (976401) [Alexa Fluor® 647] Summary

• Immunogen: Synthetic peptide containing human Adropin
  Accession # Q6UWT2
• Specificity: Detects human Adropin in direct ELISAs. Detects human and mouse Adropin in immunocytochemistry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Adropin Antibody (976401) [Alexa Fluor® 647]

• Adropin
• C9orf165
• chromosome 9 open reading frame 165
• energy homeostasis associated
• Energy homeostasis-associated protein
• ENHO
• GAAI470
• UNQ470

Background

Adropin (from the gene energy homeostasis-associated protein, ENHO) is a 76 amino acid peptide hormone encoded by the gene ENHO. Adropin levels are regulated by nutrition; a high fat diet in lean C57BL/6J mice produced rapid increase in ENHO expression. It is preferentially expressed in brain and has cardiovascular and metabolic roles in the periphery. Adropin plays a role in metabolic homeostasis, fatty acids metabolism control, insulin resistance prevention, Dyslipidemia and impaired glucose tolerance.  Adropin level is thought to be a factor in obesity because it plays a role in regulating carbohydrate, lipid and protein metabolisms by moderating glucose-mediated insulin release. High plasma levels of Adropin are associated with heart failure and body mass index. Adropin has also been shown to preserve the blood brain barrier and improve neuronal function after intracerebral hemorrhage in mice. 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.