Adrenomedullin/ADM Antibody (1003019) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: IHC
• Clone: 1003019
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Adrenomedullin/ADM Antibody (1003019) [Alexa Fluor® 594] Summary

• Immunogen: Human Adrenomedullin/ADM synthetic peptide
  Accession # P35318
• Specificity: Detects human Adrenomedullin/ADM in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Adrenomedullin/ADM Antibody (1003019) [Alexa Fluor® 594]

• ADM
• Adrenomedullin
• AMpreproadrenomedullin

Background

Adrenomedullin (ADM) is a secreted, monomeric, 6 kDa member of the adrenomedullin family of molecules.  It is widely expressed, being found in smooth muscle cells, endothelium, adrenal medulla chromaffin cells, fibroblasts and keratinocytes.  Adrenomedullin has multiple functions including vasodilation, the maintenance of vascular integrity, and the suppression of inflammatory mediator secretion.  The human Adrenomedullin preproprecursor is 185 amino acids (aa) in length.  It contains a 21 aa signal sequence, a processed 20 aa peptide termed PAMP (aa 22-41), an N-terminal propeptide (aa 45-92), the Adrenomedullin precursor (amidation is required for maturation) (aa 95-147), and a C-terminal propeptide (aa 148-185).  The Adrenomedullin precursor with a terminal Gly147 circulates naturally with bioactive, mature amidated Adrenomedullin (aa 95-146).  Depending upon the tissue, truncated forms of Adrenomedullin likely also occur, including variants spanning aa 120-146 and 128-146.  Over aa 22-147, the human Adrenomedullin proprecursor shares 70% aa identity with mouse Adrenomedullin proprecursor.       

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.