Adenosine Deaminase/ADA Antibody (EPR4438)

Product Discontinued

Adenosine Deaminase/ADA Antibody (EPR4438) Summary

• Immunogen: A synthetic peptide corresponding to residues in human ADA was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: ADA
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:250-500
  • Immunoprecipitation 1:10-100
  • Western Blot 1:1000-10000
• Theoretical MW: 41 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Reacts with: Rat, Human Does not react with Mouse

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Adenosine Deaminase/ADA Antibody (EPR4438)

• ADA
• ADA1
• adenine deaminase
• Adenosine aminohydrolase
• Adenosine Deaminase
• EC 3.5.4.4

Background

ADA is an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this protein and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADA
• Entrez:
  • 100(Human)
  • 24165(Rat)
• Uniprot:
  • P00813()