Adenosine Deaminase/ADA Products

Antibodies
Adenosine Deaminase/ADA Antib ...
Adenosine Deaminase/ADA Antibody
NBP1-87404
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Adenosine Deaminase/ADA Antib ...
Adenosine Deaminase/ADA Antibody
AF7048
Species: Hu, Mu
Applications: WB
Host: Sheep Polyclonal
Adenosine Deaminase/ADA Antib ...
Adenosine Deaminase/ADA Antibody
NBP1-90361
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
Adenosine Deaminase/ADA Antib ...
Adenosine Deaminase/ADA Antibody Pair
H00000100-AP21
Species: Hu
Applications: S-ELISA
Adenosine Deaminase/ADA Antib ...
Adenosine Deaminase/ADA Antibody Pair
H00000100-PW2
Species: Hu
Applications: WB, IP
Lysates
Adenosine Deaminase/ADA Overe ...
Adenosine Deaminase/ADA Overexpres...
H00000100-T01
Species: Hu, Pl
Applications: WB
Adenosine Deaminase/ADA Overe ...
Adenosine Deaminase/ADA Overexpres...
L024T6
Species: Hu
Applications: WB, IP
Proteins
Adenosine Deaminase/ADA Recom ...
Adenosine Deaminase/ADA Recombinan...
NBP1-72362
Species: Hu
Applications: PAGE
Adenosine Deaminase/ADA Recom ...
Adenosine Deaminase/ADA Recombinan...
H00000100-P01
Species: Hu
Applications: WB, ELISA, PA
Adenosine Deaminase/ADA Recom ...
Adenosine Deaminase/ADA Recombinan...
NBP1-90361PEP
Species: Hu
Applications: AC
RNAi
Adenosine Deaminase/ADA RNAi
Adenosine Deaminase/ADA RNAi
H00000100-R01
Species: Hu

Description

Adenosine deaminase is an enzyme involved in purine metabolism. It is needed for the breakdown of adenosine from food and from the turnover of nucleic acids in tissues. It irreversibly deaminates adenosine, converting it to the related nucleoside inosine by the removal of an amine group. Inosine can then be deribosylated (removed from ribose) by another enzyme called purine nucleoside phosphorylase (PNP), converting it to hypoxanthine. Mutations in the gene for adenosine deaminase causing it to not be expressed are one cause of severe combined immunodeficiency (SCID). Mutations causing it to be overexpressed are one cause of hemolytic anemia. There is some evidence that a different allelle (ADA2) may lead to autism. There are 2 isoforms of ADA: ADA1 and ADA2. ADA1 is found in most body cells, particularly lymphocytes and macrophages, where it is present not only in the cytosol but also as the ecto- form on the cell membrane attached to a protein called CD26. ADA2 has only been found in the macrophage where it co-exists with ADA1 where the two isoforms regulate the ratio of adenosine to deoxyadenosine to potentiate the killing of parasites. ADA2 is the predominant form present in human plasma and is increased in many diseases, particularly those associated with the immune system: for example rheumatoid arthritis, psoriasis and sarcoidosis. The plasma AD2 isoform is also increased in most cancers.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Bovine
Product By Gene ID 100
Alternate Names
  • adenine deaminase
  • ADA1
  • EC 3.5.4.4
  • Adenosine aminohydrolase
  • adenosine deaminase

Bioinformatics Tool for Adenosine Deaminase/ADA

Discover related pathways, diseases and genes to Adenosine Deaminase/ADA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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