ADAMTS5 Antibody

Images

 
Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7768] - Anti-ADAMTS5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen ...read more
Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7768] - IHC analysis of Cartilage using this antibody at 2 ug/ ml.
Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NLS7768] - Analysis of anti-ADAMTS5 antibody with human breast, carcinoma.

Product Details

Summary
Reactivity Hu, Mk, Pm, Mu, Rt, Po, Bt, Ca, Ch, Eq, Ha, Op, TrSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

ADAMTS5 Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from C-terminus of human ADAMTS5.
Specificity
Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Mouse (94%), Rat (94%), Porcine (94%), Opossum (94%), Hamster (94%), Chicken (94%), Canine (94%), Bat (94%), Turkey (94%), Equine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ADAMTS5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 2 - 4 ug/ml
Positive Control
ADAMTS5 Lysate (NBL1-07317)

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Lizard (100%), Elephant (94%), Bovine (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ADAMTS5 Antibody

  • A disintegrin and metalloproteinase with thrombospondin motifs 11
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5
  • ADAM-TS 11
  • ADAM-TS 5
  • ADAMTS11
  • ADAMTS-11
  • ADAMTS5
  • ADAM-TS5
  • ADAMTS-5
  • ADMP2
  • ADMP-2
  • ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5
  • Aggrecanase 2
  • aggrecanase-2
  • disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738
  • EC 3.4.24
  • EC 3.4.24.-
  • EC 3.4.24.14
  • EC 3.4.24.82

Background

ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ADAMTS5
Entrez