ADAMTS5 Antibody Summary
A 16 synthetic amino acid peptide within the C-terminal of human ADAMTS5.
Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Mouse (94%), Rat (94%), Porcine (94%), Canine (94%), Turkey (94%), Opossum (94%), Bat (94%), Hamster (94%), Equine (94%), Chicken (94%). Backed by our 100% Guarantee.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 2% Sucrose
0.1% Sodium Azide
Immunogen affinity purified
- Immunohistochemistry-Paraffin 2 - 4 ug/ml
Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Lizard (100%), Elephant (94%), Bovine (81%).
Alternate Names for ADAMTS5 Antibody
- A disintegrin and metalloproteinase with thrombospondin motifs 11
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2)
- ADAM metallopeptidase with thrombospondin type 1 motif, 5
- ADAM-TS 11
- ADAM-TS 5
- ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5
- Aggrecanase 2
- disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738
- EC 3.4.24
- EC 3.4.24.-
- EC 188.8.131.52
- EC 184.108.40.206
ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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