ADAMTS15 Antibody (561819) [Alexa Fluor™ Plus 594]

• Clone: 561819
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

ADAMTS15 Antibody (561819) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human ADAMTS15 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ADAMTS15 Antibody (561819) [Alexa Fluor™ Plus 594]

• A disintegrin and metalloproteinase with thrombospondin motifs 15
• a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 15
• a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 15, preproprotein
• ADAM metallopeptidase with thrombospondin type 1 motif, 15
• ADAM-TS 15
• ADAMTS15
• ADAM-TS15
• ADAMTS-15
• EC 3.4.24
• EC 3.4.24.-
• EC 3.4.24.14
• EC 3.4.24.82
• metalloprotease disintegrin 15 with thrombospondin domains
• MGC126403

Background

A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15) is a secreted multi-domain protease that is primarily expressed in fetal liver and kidney. ADAMTS1, 4, 5, 8, and 15 form a subfamily of ADAMTS proteases that possess aggrecanase activity. These proteins are synthesized as zymogens which have a pro-domain that is removed by furin-like protein convertases. ADAMTS15 functions as a suppressor of tumor growth and invasion. It is downregulated in colon cancer, and its expression in breast cancer correlates with poor prognosis. Within amino acids (aa) 18-682 (which includes the propeptide, peptidase, disintegrin, first TSP-1 and most of the Cys-rich domain), human ADAMTS15 shares 95% aa sequence identity with mouse and rat ADAMTS15.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.