Actin Alpha 1 Cardiac Muscle Antibody (22D3) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Gt, Ma, Rb, Xp, ZeSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clone
22D3
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750

Actin Alpha 1 Cardiac Muscle Antibody (22D3) [Alexa Fluor® 750] Summary

Immunogen
Clone 22D3 is a mouse monoclonal IgG1 antibody derived by fusion of NS0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a peptide comprising the N-terminal nonapeptide of alpha-cardiac actin with an acetylated N-terminus (Ac-DDEETTALVC-COOH) coupled to keyhole limpet hemocyanin through the cysteine residue.
Specificity
Clone 22D3 is an antibody highly specific for a- cardiac actin, and does not cross react with other actin isoforms.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ACTC1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Bovine reactivity reported in scientific literature (PMID: 30591979). Mouse reactivity reported in scientific literature (PMID: 28624189).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Actin Alpha 1 Cardiac Muscle Antibody (22D3) [Alexa Fluor® 750]

  • ACTC
  • ACTC1
  • actin, alpha, cardiac muscle 1
  • alpha-Cardiac Actin
  • ASD5
  • Cardiac alpha-Actin
  • CMD1R
  • CMH11
  • LVNC4

Background

Actin, alpha cardiac muscle 1 (ACTC1) is a 377 aa cytoskeletal filament in cardiac muscle which interacts with the 50-KDa domain of the myosin motor domain in cardiac muscle contraction. Actin is highly conserved across species, and differs from skeletal muscle actin (ACTA1) by only four amino acids. Mutations in the ACTC1 gene are linked to familial hypertrophy cardiomyopathy, atrial septal defects, arrhythmia, and chronic inflammatory cardiomyopathy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Actin Alpha 1 Cardiac Muscle Antibody (NBP1-97725AF750) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-97725AF350
Alexa Fluor 405 NBP1-97725AF405
Alexa Fluor 488 NBP1-97725AF488
Alexa Fluor 532 NBP1-97725AF532
Alexa Fluor 594 NBP1-97725AF594
Alexa Fluor 647 NBP1-97725AF647
Alexa Fluor 700 NBP1-97725AF700
Alexa Fluor 750 NBP1-97725AF750
DyLight 350 NBP1-97725UV
DyLight 405 NBP1-97725V
DyLight 488 NBP1-97725G
DyLight 550 NBP1-97725R
DyLight 594 NBP1-97725DL594
DyLight 650 NBP1-97725C
DyLight 680 NBP1-97725FR
DyLight 755 NBP1-97725IR
Janelia Fluor 549 NBP1-97725JF549
Janelia Fluor 646 NBP1-97725JF646

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Bioinformatics Tool for Actin Alpha 1 Cardiac Muscle Antibody (NBP1-97725AF750)

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Contact Information

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Product PDFs

Calculators

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Bioinformatics

Gene Symbol ACTC1
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